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Early-stage Parkinson's disease(EPD)is often clinically asymmetric.We used F-fluorodeoxyglucose(FDG)and PET to assess whether EPD can be detected by a characteristic pattern of regional metabolic asymmetry.To identify this pattern,we studied 10 EPD(Hoehn and Yahr stage I)patients(mean age 61.1+/- 11.1 years)using F-FDG and PET to calculate regional metabolic rates for glucose.Subject scores for this profile accurately discriminate EPD patients from normal subjects and A patients(p<0.0001).Group assignments into normal or parkinsonian categories with FDG/PET were comparable to those achieved with FDOPA/PET,although AP and EPD patients were not differentiable by the latter method.Metabolic brain imaging with FDG/PET may be useful in the differential diagnosis of EPD. |
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CAT scan,emission
CAT scan,emission,abnormal
neurologic disease,diagnoses of
Parkinson disease
Parkinson disease,diagnosis
Parkinson disease,differential diagnosis of
Parkinson disease,early symptoms
Parkinson disease,L-dopa nonresponsive
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